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Depression Database: Genetic Factors: Transporters: SLCO1C1 (solute carrier organic anion transporter family, member 1C1)

SLCO1C1 (solute carrier organic anion transporter family, member 1C1)

Other Symbols:

OATP-F, OATP1, OATP1C1, OATPRP5, SLC21A14

Disease relevance:

This gene belongs to the organic anion transporter family. It is a thyroid hormone transporter found at the blood-brain barrier. Polymorphisms in the gene, especially OATP1C1-intron3C > T and the OATP1C1-C3035T, are related [...] http://digg.com/u1Ujew

Depression Database: Genetic Factors: Transporters: SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

Other Symbols:

5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, hSERT

1) Disease relevance:

This gene belongs to the sodium:neurotransmitter symporter family and is incharge of transporting the neurotransmitter serotonin from synaptic spaces to presynaptic neurons. It is an important regulator of the serotonergic [...] http://digg.com/u1UXwT

Depression Database: Genetic Factors: Transporters: SLC6A3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)

SLC6A3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)

Other Symbols:

DAT, DAT1

1) Disease relevance:

This gene is a dopamine transporter. It belongs to the sodium- and chloride-dependent neurotransmitter transporter family. Variations in the gene are linked to idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, and susceptibility to [...] http://digg.com/u1UHxc

Depression Database: Genetic Factors: Transporters: SLC6A2 (solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2)

SLC6A2 (solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2)

Other Symbols:

NAT1, NET, NET1, SLC6A5

Disease relevance:

This gene is a member of the sodium:neurotransmitter symporter family. It is involved in the regulation of norepinephrine homeostasis and central nervous monoaminergic homeostasis. It is one of the primary targets of many antidepressants. Dysfunction [...] http://digg.com/u1UE85

Depression Database: Genetic Factors: Transporters: ABCA13 (ATP-binding cassette, sub-family A (ABC1), member 13)

ABCA13 (ATP-binding cassette, sub-family A (ABC1), member 13)

Other Symbols:

DKFZp313D2411, FLJ16398, FLJ33876, FLJ33951

Disease relevance:

This gene is belongs to the ABC gene subfamily A (ABCA) and is a lipid transporter gene. It is found to be a candidate gene in schizophrenia, bipolar disorder, and depression (Knight et al., 2009).

Sample size:

100 cases with [...] http://digg.com/u1TsiZ

Inflammation Database: genes: AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8))

AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8))

[ANHU, FLJ92595, FLJ97926, SERPINA8]

- Hyperglycemia may be related to the adverse renal effects of angiotensin II (AII). In the kidney, the glomerular mesangial cell is the main target of AII action. Glucose augments angiotensin II-induced proinflammatory gene expression in human mesangial cells (Naito et al., 2009). AII [...] http://digg.com/u1Rh2n

Inflammation Database: genes involved in inflammation: AGER (advanced glycosylation end product-specific receptor)

AGER (advanced glycosylation end product-specific receptor)

[DAMA-358M23.4, MGC22357, RAGE]

- This gene belongs to the immunoglobulin superfamily of cell surface molecules (RefSeq, 2010). Higher oxidant stress and inflammation (OS/infl) have been associated with aging-related diseases and advanced glycation end products (AGEs). AGE receptor-1 (AGER1) is an antioxidant and can reduce OS/infl. Reduction of AGEs in normal diets [...] http://digg.com/u1RbjN